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Refractory hypertension is associated with the haptoglobin 2-2 phenotype
J R Delanghe1, D A Duprez, M L De Buyzere
1Department of Clinical Chemistry, University Hospital, Gent, Belgium.
Journal of Cardiovascular Risk
|April 1, 1995
Summary
The haptoglobin 2-2 phenotype is associated with a higher risk of developing refractory hypertension. This finding may help identify individuals predisposed to difficult-to-treat high blood pressure.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Biochemistry
Background:
- Refractory hypertension often lacks identifiable causes.
- Haptoglobin polymorphism is a potential genetic marker for essential hypertension.
Purpose of the Study:
- To investigate haptoglobin (Hp) type distribution in refractory hypertension patients.
- To determine if Hp polymorphism is linked to treatment-resistant hypertension.
Main Methods:
- Studied Hp polymorphism in 383 non-refractory and 62 refractory hypertension patients.
- Utilized starch gel electrophoresis for Hp typing.
Main Results:
- Haptoglobin 1 allele frequency was lower in refractory hypertension (0.266) vs. non-refractory (0.385).
- Haptoglobin 2-2 phenotype frequency was higher in refractory (56%) vs. non-refractory (39%) groups.
- Haptoglobin 2-2 was most frequent (75%) in refractory patients needing multiple medications.
Conclusions:
- The haptoglobin 2-2 phenotype indicates a higher risk for developing refractory hypertension.
- Hp typing may aid in predicting hypertension severity and treatment resistance.