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Localisation of insulinomas

R C Turner, E C Lee, P J Morris

    Lancet (London, England)
    |March 11, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Catheterization of splenic and portal veins can precisely locate small insulinomas missed by other methods. This improved localization allows for targeted pancreatic surgery, avoiding extensive medical treatment before operation.

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    Area of Science:

    • Endocrinology
    • Surgical Oncology
    • Diagnostic Imaging

    Background:

    • Small insulinomas are often difficult to detect using conventional methods like arteriography or palpation.
    • Accurate localization of insulinomas is crucial for effective surgical planning and treatment.

    Purpose of the Study:

    • To evaluate the efficacy of venous sampling via catheterization for localizing small, undetectable insulinomas.
    • To demonstrate how improved localization impacts surgical strategy and patient outcomes.

    Main Methods:

    • Utilized catheterization of splenic and portal veins to sample venous effluent at multiple sites.
    • Employed percutaneous transhepatic and intraoperative laparotomy routes for venous sampling.
    • Correlated high insulin levels in specific venous samples with tumor location.

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    Main Results:

    • Successfully identified small insulinomas that were previously undetectable by arteriography or palpation.
    • Enabled precise localization of tumors within the pancreas (e.g., head or body).
    • Facilitated the resection of only the affected pancreatic segment, preserving healthy tissue.

    Conclusions:

    • Venous sampling via catheterization is a highly effective method for localizing small insulinomas.
    • Accurate tumor localization improves surgical planning, enabling targeted resection and potentially avoiding lengthy medical therapy.