Nuclear tau immunoreactivity in presenile dementia with motor neuron disease: a case report

We report for the first time localization of tau immunoreactivity with neuronal nuclei in an autopsy case of a 64-year-old white male with a 10-year history of presenile dementia with motor neuron disease. The anti-tau mAbs Tau-1, Tau-2, Tau-5 and PHF-1 and the anti-phosphoneurofilament mAb SMI-31, which crossreacts with tau, stained neuronal nuclei in neocortical pyramidal layer V or in layer III of primary motor cortex, in the periamygdaloid and entorhinal cortices, in pons and in a few paramedian neurons in dorsal medulla. The staining was excluded from nucleoli.