Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unipolar depression: is it divisible into autonomous subtypes?

G Winokur

    Archives of General Psychiatry
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cross-cultural psychotherapy. M. M. Bishop and G. Winokur (1956). Reprinted from the J Nerv Ment Dis. 123: 369-375.

    The Journal of nervous and mental disease·2012
    Same author

    Alcoholism and drug abuse in three groups--bipolar I, unipolars and their acquaintances.

    Journal of affective disorders·1998
    Same author

    Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder.

    Journal of affective disorders·1998
    Same author

    Quantitative analysis of leukocyte mitochondrial DNA deletion in affective disorders.

    Biological psychiatry·1997
    Same author

    All roads lead to depression: clinically homogeneous, etiologically heterogeneous.

    Journal of affective disorders·1997
    Same author

    The effect of gender and age at onset of depression on mortality.

    The Journal of clinical psychiatry·1997
    Same journal

    Reviewers Who Completed a Review During 2011.

    Archives of general psychiatry·2017
    Same journal

    Conflicts of interest-reply.

    Archives of general psychiatry·2013
    Same journal

    Epidemiologic evidence concerning the bereavement exclusion in major depression-reply.

    Archives of general psychiatry·2013
    Same journal

    This month in archives of general psychiatry.

    Archives of general psychiatry·2013
    Same journal

    About this journal.

    Archives of general psychiatry·2013
    Same journal

    This month in archives of general psychiatry.

    Archives of general psychiatry·2013
    See all related articles

    Depression spectrum disease, characterized by family history of alcoholism or antisocial personality, presents differently than pure depression. This distinction may involve genetic links and varied illness courses.

    Area of Science:

    • Psychiatry
    • Genetics
    • Clinical Psychology

    Background:

    • Depression spectrum disease is defined by a first-degree family history of alcoholism and/or antisocial personality.
    • Pure depressive disease is characterized by a family history of depression without alcoholism.
    • These distinctions suggest potentially different underlying mechanisms and clinical presentations.

    Purpose of the Study:

    • To differentiate depression spectrum disease from pure depressive disease.
    • To investigate differences in the clinical course and potential genetic links between these depressive illness subtypes.
    • To provide a more rigorous definition for depression spectrum disease.

    Main Methods:

    • Comparative analysis of patient groups based on family history of psychiatric conditions.

    Related Experiment Videos

  • Clinical observation and assessment of illness variability, personality traits, and interpersonal conflicts.
  • Preliminary investigation of genetic markers (C3, alpha-haptoglobin) in relation to depression subtypes.

    • Main Results:

    • Depression spectrum disease exhibits greater variability in its course compared to pure depressive disease.
    • Patients with depression spectrum disease report more personality problems and interpersonal conflict.
    • Preliminary data suggest a potential association between depression spectrum disease and genetic markers like C3 or alpha-haptoglobin.

    Conclusions:

    • Depression spectrum disease and pure depressive disease represent distinct entities with differing clinical trajectories.
    • The findings support the concept of depression spectrum disease as a clinically and potentially genetically distinct condition.
    • Further research into genetic markers may elucidate the etiology of depression spectrum disease.