Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous opioids may modulate catecholamine secretion during high intensity exercise

T J Angelopoulos1, B G Denys, C Weikart

  • 1Human Energy Research Laboratory, University of Pittsburgh, PA 15261, USA.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergent climate impacts despite similar response to temperature in a widespread aerial insectivore.

bioRxiv : the preprint server for biology·2025
Same author

Intraseasonal effects of clutch manipulation on parental provisioning and residual reproductive value of eastern phoebes (Sayornis phoebe).

Oecologia·2017
Same author

Brood size and the cost of provisioning nestlings: interpreting Lack's hypothesis.

Oecologia·2017
Same author

Cross-validation of Peak Oxygen Consumption Prediction Models From OMNI Perceived Exertion.

International journal of sports medicine·2016
Same author

Aerobic Requirements for Moving Handweights Through Various Ranges of Motion While Walking.

The Physician and sportsmedicine·2016
Same author

Added sugars and risk factors for obesity, diabetes and heart disease.

International journal of obesity (2005)·2016

Endogenous opioids inhibit catecholamine release during intense exercise. Naloxone administration increased epinephrine, norepinephrine, glucose, and lactate levels compared to placebo.

Area of Science:

  • Exercise Physiology
  • Neuroendocrinology

Background:

  • Endogenous opioids play a role in modulating physiological responses to stress.
  • Intense exercise triggers significant neuroendocrine adaptations, including catecholamine release.

Purpose of the Study:

  • To investigate the inhibitory effect of endogenous opioids on catecholamine (epinephrine and norepinephrine) response during high-intensity exercise.
  • To examine the influence of opioid blockade on glucose and lactate metabolism during exercise.

Main Methods:

  • Nine fit male subjects performed two 20-minute treadmill exercise trials at 80% maximal oxygen uptake (VO2max).
  • Subjects received either naloxone (an opioid antagonist) or a placebo in a double-blind, counterbalanced design.
  • Blood samples were collected at baseline and after exercise to measure catecholamines, glucose, and lactate.

Related Experiment Videos

Main Results:

  • Epinephrine and norepinephrine levels were significantly higher (P < 0.05) in the naloxone trial compared to placebo.
  • Glucose and lactate concentrations were also elevated (P < 0.05) in the naloxone trial.
  • Mean epinephrine: 1679 (N) vs 1196 (P) pmol/L; Norepinephrine: 24 (N) vs 20 (P) nmol/L.

Conclusions:

  • Endogenous opioids appear to exert an inhibitory influence on catecholamine release during intense exercise.
  • Opioid system modulation affects metabolic responses, including glucose and lactate, during strenuous physical activity.