Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioavailability of chlorpropamide

M Evans, R C Glass, M Mitchard

    British Journal of Clinical Pharmacology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Synthesis and degradation of sodium iron phosphate glasses and their in vitro cell response.

    Journal of biomedical materials research. Part A·2004
    Same author

    Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function.

    Thyroid : official journal of the American Thyroid Association·2004
    Same author

    Acupuncture associated pneumothorax.

    Emergency medicine journal : EMJ·2004
    Same author

    Low-dose computed tomography surveillance of patients with testicular tumours.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2004
    Same author

    The public health response to a case of Lassa fever in London in 2000.

    The Journal of infection·2004
    Same author

    Assessing mental health in primary care research using standardized scales: can it be carried out over the telephone?

    Psychological medicine·2004
    Same journal

    N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

    British journal of clinical pharmacology·2026
    Same journal

    The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

    British journal of clinical pharmacology·2026
    Same journal

    Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

    British journal of clinical pharmacology·2026
    Same journal

    UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

    British journal of clinical pharmacology·2026
    See all related articles

    Serum profiles of chlorpropamide (an antidiabetic medication) were compared across different formulations in healthy volunteers. Absorption rates varied, with suspension showing faster chlorpropamide absorption than tablets, impacting blood glucose levels.

    Area of Science:

    • Pharmacokinetics
    • Pharmacology
    • Drug Formulation

    Background:

    • Chlorpropamide is an oral hypoglycemic agent used in type 2 diabetes management.
    • Understanding formulation-dependent drug absorption is crucial for optimizing therapeutic efficacy.
    • Variations in drug release profiles can influence patient outcomes.

    Purpose of the Study:

    • To compare the serum profiles of chlorpropamide from two tablet formulations and one suspension.
    • To assess the impact of different chlorpropamide formulations on absorption rates.
    • To correlate drug serum profiles with changes in blood glucose concentrations.

    Main Methods:

    • Single-dose administration of chlorpropamide formulations to healthy volunteers.
    • Serum chlorpropamide levels were monitored over time.

    Related Experiment Videos

  • Blood glucose concentrations were measured and analyzed.
  • Pharmacokinetic parameters were compared across formulations.

    • Main Results:

    • Similar overall absorption amounts of chlorpropamide were observed for all three formulations.
    • The suspension formulation demonstrated significantly faster absorption of chlorpropamide compared to both tablet formulations.
    • A minor, therapeutically insignificant difference in absorption rate was noted between the two tablet formulations.
    • Changes in blood glucose levels correlated with the observed serum concentration-time profiles of chlorpropamide.

    Conclusions:

    • The rate of chlorpropamide absorption is formulation-dependent, with suspensions offering faster absorption.
    • While total absorption is comparable, the differential absorption rates can influence the pharmacodynamic effects, such as blood glucose reduction.
    • These findings highlight the importance of considering formulation characteristics in chlorpropamide therapy.