Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal microvasculature in diabetic neuropathy

J D Ward1

  • 1Royal Hallamshire Hospital, Sheffield, UK.

Eye (London, England)
|January 1, 1993
PubMed
Summary

Diabetic neuropathy involves microvascular changes in nerves, similar to the eyes and kidneys. Targeting these nerve blood vessel abnormalities is crucial for effective treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies.

Placenta·2022
Same author

An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans.

Genetics·2021
Same author

Aerosolisation during tracheal intubation and extubation in an operating theatre setting.

Anaesthesia·2020
Same author

Effects of methionine and lysine on fermentation in vitro and in vivo, nutrient flow to the intestine, and milk production.

Journal of dairy science·2006
Same author

Sural nerve pathology in diabetic patients with minimal but progressive neuropathy.

Diabetologia·2005
Same author

Effects of zinc and sodium monensin on ruminal degradation of lysine-HCl and liquid 2-hydroxy-4-methylthiobutanoic acid.

Journal of dairy science·2004

Area of Science:

  • Diabetology
  • Neurology
  • Vascular Biology

Background:

  • Diabetic complications prominently affect the retina and kidney.
  • Nerve damage is a common yet poorly understood complication of diabetes.
  • Previous biochemical theories for nerve damage lack effective treatments.

Purpose of the Study:

  • To investigate microvascular abnormalities in diabetic neuropathy.
  • To identify structural and functional changes in nerve vasculature.
  • To guide therapeutic interventions for diabetic nerve damage.

Main Methods:

  • Examination of human sural nerve microvasculature.
  • Assessment of endothelial basement membrane and cell proliferation.
  • Evaluation of nerve hypoxia and arteriovenous shunting.
  • Analysis of fluorescein flow and nerve conduction.

Main Results:

  • Significant microvascular changes observed in diabetic neuropathy.
  • Endothelial thickening and luminal occlusion are present.
  • Nerves exhibit hypoxia, arteriovenous shunting, and impaired fluorescein flow.
  • Nerve conduction abnormalities correlate with vascular changes.

Conclusions:

  • Diabetic neuropathy involves significant microvascular structural and functional damage.
  • These vascular changes are likely key contributors to nerve damage.
  • Therapeutic strategies should focus on correcting these microvascular abnormalities.

Related Experiment Videos