Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Autism in tuberous sclerosis]

R Calderón González1, J Treviño Welsh, A Calderón Sepúlveda

  • 1Departamento de Neurología, Instituto de Estudios Neuropediátricos, A.C. Monterrey, N.L.

Gaceta Medica De Mexico
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Gilles de la tourette syndrome: clinical spectrum and management].

Revista de neurologia·2003
Same author

[Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents].

Boletin medico del Hospital Infantil de Mexico·1991
See all related articles

Tuberous sclerosis is linked to autism in children. Frontotemporal tubers may influence autistic behaviors, with 25.9% of patients showing autistic disorder symptoms.

Area of Science:

  • Neurology
  • Developmental Pediatrics
  • Genetics

Background:

  • Tuberous sclerosis complex (TSC) is a genetic disorder.
  • High incidence of autism spectrum disorder (ASD) observed in children with TSC.
  • Potential link between tuber location and autistic behaviors suggested.

Purpose of the Study:

  • Investigate the association between TSC and ASD.
  • Examine the role of tuber localization in autistic behaviors within TSC patients.
  • Report clinical and neuroimaging findings in TSC children with ASD.

Main Methods:

  • Retrospective study of 27 children diagnosed with TSC (1988-1990).
  • Diagnosis confirmed by clinical, MRI, and/or CT findings.
  • DSM-III-R criteria used for ASD diagnosis; neuroimaging analyzed for tuber location.

Related Experiment Videos

Main Results:

  • Seven out of 27 TSC children (25.9%) met DSM-III-R criteria for ASD.
  • Autistic behaviors were evident by 3.5 years; all seven had mental retardation.
  • Frontal and temporoparietal tubers were present in 5/7 autistic TSC children; 5/7 also had West syndrome.

Conclusions:

  • A significant association exists between tuberous sclerosis and autism.
  • Frontal and temporoparietal tuber location may correlate with autistic disorder in TSC.
  • Further research into the neurobiological underpinnings of ASD in TSC is warranted.