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Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue
K L Puranam1, E Kennington, S N Sait
1Howard Hughes Medical Institute Laboratories, Department of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Abstract:
We have determined the chromosomal location of the human and mouse genes encoding the RECQL protein, a putative DNA helicase homologous to the bacterial DNA helicase, RecQ. RECQL was localized to human chromosome 12 by analysis of human-rodent somatic cell hybrid DNA; fine mapping of RECQL by fluorescence in situ hybridization revealed its chromosomal location to be 12p11-p12. The corresponding mouse gene, Recql, was mapped to the telomeric end of mouse chromosome 6 by analysis of DNA from an interspecific cross.
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