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Left ventricular and aortic root structure and function changes with beta blocker antihypertensive therapy. A

G P Vyssoulis1, M A Valiouli, E A Karpanou

  • 1Department of Cardiology, University of Athens, Greece.

International Journal of Cardiology
|March 24, 1995
PubMed

Insights

Celiprolol therapy significantly improved cardiovascular function in hypertensive patients compared to metoprolol. This long-term treatment reduced peripheral resistance and left ventricular hypertrophy, enhancing diastolic and aortic root function.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension management requires effective therapies targeting cardiovascular structure and function.
  • Beta-blockers are commonly used, but their comparative effects on cardiac hemodynamics and vascular properties require further investigation.

Purpose of the Study:

  • To compare the long-term effects of celiprolol versus metoprolol on hemodynamic parameters, left ventricular structure and function, and aortic root distensibility in hypertensive patients.

Main Methods:

  • Echocardiographic and Doppler methodologies were employed.
  • Forty hypertensive patients received either celiprolol (200-400 mg/day) or metoprolol (100-200 mg/day) for one year.

Main Results:

  • Celiprolol significantly reduced total peripheral resistance (-11.2%) and left ventricular mass index (-11.8%) compared to metoprolol. Both drugs increased aortic root distensibility, with celiprolol showing a greater effect (80% vs. 30%). Celiprolol also improved left ventricular diastolic function.
  • Cardiac index decreased significantly with metoprolol (-13.9%) but only marginally with celiprolol (-5.9%).

Conclusions:

  • Long-term antihypertensive therapy with celiprolol offers superior benefits over metoprolol.
  • Celiprolol improves left ventricular diastolic function, aortic root distensibility, reduces peripheral resistance, and mitigates left ventricular hypertrophy in hypertensive patients.

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