Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medulloblastoma in adults

P J Frost1, N J Laperriere, C S Wong

  • 1Department of Radiation Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada.

International Journal of Radiation Oncology, Biology, Physics
|July 15, 1995
PubMed
Summary

Adult medulloblastoma patients treated with radiotherapy had a 7.9-year median survival. Factors like M stage, functional status, and hydrocephalus impacted disease-free survival, while gross total resection improved posterior fossa control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Future of Multidisciplinary Team in the Context of Adaptive Therapy.

Seminars in radiation oncology·2024
Same author

Validation of the emergency surgery score (ESS) in a UK patient population and comparison with NELA scoring: a retrospective multicentre cohort study.

Annals of the Royal College of Surgeons of England·2024
Same author

Laparoscopic large hiatus hernia repair with mesh reinforcement versus suture cruroplasty alone: a systematic review and meta-analysis.

Hernia : the journal of hernias and abdominal wall surgery·2023
Same author

COVID toe in an adolescent boy: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2022
Same author

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2022
Same author

Fate of thiamethoxam from treated seeds in mesocosms and response of aquatic invertebrate communities.

Ecotoxicology (London, England)·2022

Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Clinical Outcomes Research

Background:

  • Medulloblastoma is a primary brain tumor predominantly affecting children but also occurring in adults.
  • Postoperative radiotherapy is a cornerstone of medulloblastoma treatment.
  • Long-term outcomes and prognostic factors in adult medulloblastoma patients treated with radiotherapy require further elucidation.

Purpose of the Study:

  • To evaluate the survival outcomes for adult medulloblastoma patients treated with postoperative radiotherapy.
  • To identify prognostic factors influencing disease-free survival and recurrence patterns in this patient cohort.

Main Methods:

  • Retrospective review of 48 adult patients (≥16 years) with medulloblastoma treated between 1958 and 1988.
  • Analysis included patient demographics, tumor characteristics (location, variant), surgical resection extent, and radiotherapy details (craniospinal vs. local).

Related Experiment Videos

  • Statistical analysis assessed factors affecting overall survival, disease-free survival, and patterns of recurrence.

    • Main Results:

    • Median overall survival was 7.9 years, with 5-year and 10-year survival rates of 62% and 41%, respectively.
    • Significant predictors of disease-free survival included M stage (M0 vs. M1-4), functional status (1-2 vs. 3-5), and preoperative hydrocephalus.
    • Subtotal tumor removal was associated with an increased risk of posterior fossa relapse (p = 0.04).

    Conclusions:

    • Adult medulloblastoma patients with advanced M stage, poor functional status, or preoperative hydrocephalus experience worse disease-free survival.
    • Gross total resection of the tumor is crucial for improving local control within the posterior fossa.
    • These findings underscore the importance of comprehensive staging and optimal surgical management in conjunction with radiotherapy for adult medulloblastoma.