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Cyclin A links c-Myc to adhesion-independent cell proliferation
J F Barrett1, B C Lewis, A T Hoang
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
The Journal of Biological Chemistry
|July 7, 1995
Abstract:
Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.