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Related Experiment Videos

Does hemispheric dominance influence brain lesion distribution in multiple sclerosis?

M Filippi1, G Martino, S Mammi

  • 1Department of Neurology, University of Milano, San Raffaele Scientific Institute, Italy.

Journal of Neurology, Neurosurgery, and Psychiatry
|June 1, 1995
PubMed
Summary

Multiple sclerosis (MS) brain lesions show a preference for the dominant hemisphere, correlating with hand preference. This suggests hemispheric specialization may influence MS lesion vulnerability.

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease.
  • The distribution of MS lesions between brain hemispheres is not fully understood.
  • Cerebral function is often lateralized, with specialized roles in each hemisphere.

Purpose of the Study:

  • To investigate the relationship between hemispheric lesion distribution in MS and the localization of cerebral function.
  • To determine if hand preference, an indicator of cerebral dominance, correlates with lesion asymmetry in MS patients.

Main Methods:

  • A cohort of 23 patients with clinically definite multiple sclerosis (MS) was studied.
  • Hand preference was assessed using a 10-item self-administered questionnaire.
  • Supratentorial brain Magnetic Resonance Imaging (MRI) was performed to quantify lesion volumes in each hemisphere.

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Main Results:

  • A significant correlation was found between the degree of hand preference and the index of interhemispheric lesion distribution (P = 0.02).
  • The left hemisphere showed a higher median lesion volume (7275 mm3) compared to the right hemisphere (5385 mm3).
  • Individual patient data revealed a wide range in both hand preference and lesion distribution.

Conclusions:

  • The findings suggest that the dominant hemisphere may be more vulnerable to the pathological processes in MS.
  • Local events, potentially linked to hemispheric functional specialization, could explain the observed lesion asymmetry.
  • Further research is warranted to elucidate the mechanisms underlying hemispheric vulnerability in MS.