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Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus pneumoniae meningitis
M Muñoz1, E S Valderrabanos, E Diaz
1Department of Pediatrics, Virgen Rocio Children's Hospital, Seville University School of Medicine, Spain.
The Journal of Pediatrics
|July 1, 1995
Abstract:
A young boy had meningitis caused by Streptococcus pneumoniae that was relatively resistant to penicillin and susceptible to cefotaxime. After 10 days of therapy with penicillin and cefotaxime, fever recurred and a second lumbar puncture revealed a pneumococcus that was resistant to all beta-lactam antibiotics. We now add vancomycin to empiric third-generation cephalosporin therapy for meningitis in children when gram-positive cocci are seen on the cerebrospinal fluid smear.