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Microsatellite polymorphisms reveal phylogenetic relationships in primates

E Meyer1, P Wiegand, S P Rand

  • 1Institut für Rechtsmedizin, Westfälische Wilhelms-Universität Münster, Germany.

Journal of Molecular Evolution
|July 1, 1995
PubMed
Summary

Researchers studied microsatellite DNA in nonhuman primates, finding shorter repeat arrays than in humans. These findings suggest an ancient precursor state and link repeat numbers to primate evolutionary divergence times.

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Area of Science:

  • Genetics
  • Primate evolution
  • Molecular anthropology

Background:

  • Microsatellites are repetitive DNA sequences.
  • Tyrosine hydroxylase (TH01) and von Willebrand factor (VWA) genes contain polymorphic microsatellites in humans.
  • Nonhuman primates offer insights into human genetic history.

Purpose of the Study:

  • To analyze microsatellite variation in TH01 and VWA genes across ten nonhuman primate genera.
  • To compare nonhuman primate microsatellite data with human populations.
  • To investigate the relationship between microsatellite repeat numbers and primate divergence times.

Main Methods:

  • Polymerase chain reaction (PCR) amplification of specific gene introns.
  • Microsatellite typing in ten nonhuman primate genera.

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  • DNA sequencing of von Willebrand factor (VWA) orthologues.

    • Main Results:

    • Shorter microsatellite repeat arrays were observed in nonhuman primates compared to humans.
    • A correlation was found between the average number of repeats and the divergence time of primate genera from humans.
    • High variability in repeat arrangement was detected in VWA 5'-repeat arrays.

    Conclusions:

    • Nonhuman primate microsatellites may represent an ancestral state.
    • Microsatellite evolution is linked to primate evolutionary history.
    • Polar mutational events likely contribute to microsatellite variability in VWA genes.