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B-lymphocyte requirement for vaccine-mediated protection from Theiler's murine encephalomyelitis virus-induced
C I Kurtz1, X M Sun, R S Fujinami
1Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA.
Abstract:
The role of humoral immunity in the protection of vaccinated SJL/J mice from central nervous system disease induced by the DA strain (DAV) of Theiler's murine encephalomyelitis virus was investigated in B-cell-deficient mice. Mice were depleted of B cells by treatment with a mouse monoclonal antibody specific for immunoglobulin M. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease. CD4+ T cells are required in this model of protection to provide help for the development of an antiviral antibody response in the central nervous system.