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Updated: Jul 13, 2026
Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
Suppression by prolactin of the electrically induced erectile response through its direct effect on the corpus
H Aoki1, T Fujioka, J Matsuzaka
1Department of Urology, Iwate Medical University, School of Medicine, Japan.
Purpose:
Men become impotent when exposed to hyperprolactinemia. To clarify its mechanisms the effects of intracorporal infusion of prolactin on electrically induced penile erection were evaluated in 12 male dogs.
Materials And Methods:
Prolactin (10 micrograms./ml.) or control saline was directly infused into the corpus cavernosum penis 5 minutes before electrical pulse stimulation of the pelvic nerve and the intracorporal pressure was monitored.
Results:
In 8 dogs erection was markedly suppressed or completely abolished by prolactin. In the remaining 4, this effect of prolactin became manifest only when the ipsilateral internal pudenal artery was ligated. Saline infusion was without effect.
Conclusions:
An excess of prolactin directly inhibited the smooth muscle relaxation of corpus cavernosum penis.
