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Updated: Aug 11, 2026
Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
Published on: December 30, 2014
Effects of alpha-blocker on sperm concentration, motility, intraluminal pressure and fluid movement in the rat cauda
1Department of Urology, Nagoya University School of Medicine, Japan.
Purpose:
To investigate whether alpha blocker has an effect on epididymal sperm parameters, intraluminal pressure and fluid movement.
Materials And Methods:
Sprague-Dawley rats were given daily oral doses 1 mg./kg., 2 mg./kg., or 10 mg./kg. of Bunazosin, a selective alpha blocker, for 1 month. A micropuncture technique was used to collect intraluminal fluids.
Results:
Epididymal sperm concentrations were significantly increased. Progressive motility of spermatozoa was not altered. Intraluminal pressures were significantly reduced, and intraluminal fluid movement rates were significantly increased.
Conclusion:
Alpha blocker has an effect on sperm transport and storage in the rat testis and epididymis.
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