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Related Experiment Video

Updated: Jul 12, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Long-term survival and function after suspected gram-negative sepsis

T M Perl¹, L Dvorak, T Hwang

¹Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.

|July 26, 1995

Summary

Severe underlying illness and vasopressor use predict sepsis survival. Survivors often experience physical dysfunction and poorer general health, though emotional health may improve.

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Last Updated: Jul 12, 2026

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Area of Science:

Critical Care Medicine
Infectious Diseases
Epidemiology

Background:

Gram-negative sepsis poses a significant threat to patient survival and long-term health.
Predicting long-term outcomes in sepsis patients is crucial for resource allocation and patient management.

Purpose of the Study:

To determine long-term survival rates (> 3 months) in patients with gram-negative sepsis.
To develop predictive models for long-term sepsis survival.
To assess the health and functional status of sepsis survivors.

Main Methods:

A cohort of 100 patients with suspected gram-negative sepsis were followed for a median of 7667 patient-months.
Cox proportional hazard regression models were used to identify predictors of long-term survival.
Health and functional status were measured using validated scoring systems and compared to general population norms.

Main Results:

Severity of underlying illness (McCabe and Jackson criteria) and vasopressor use were significant predictors of mortality.
Adult respiratory distress syndrome and comorbid illnesses also predicted poor long-term survival.
Sepsis survivors reported increased physical dysfunction and poorer general health perception, but improved emotional health perception.

Conclusions:

Underlying illness severity and vasopressor use at the onset of sepsis strongly predict both short- and long-term survival.
The McCabe and Jackson severity scoring system is validated for predicting long-term sepsis survival.
Physical dysfunction and diminished general health perception are common sequelae of sepsis, necessitating continued patient support.