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Premature ovarian failure: morphological and ultrastructural aspects
M A Haidar1, E C Baracat, M J Simões
1Department of Obstetrics and Gynecology, Escola Paulista de Medicina, São Paulo, Brazil.
Sao Paulo Medical Journal = Revista Paulista De Medicina
|April 1, 1994
Summary
Premature ovarian failure (POF) in women shows dense ovarian connective tissue and few corpora albicantia. Ovarian follicles were largely absent, with rare atypical follicles and one corpus luteum observed.
Area of Science:
- Reproductive Biology
- Pathology
- Histology
Background:
- Premature ovarian failure (POF) is a condition affecting women of reproductive age.
- Understanding the ovarian morphology in POF is crucial for diagnosis and potential treatments.
Purpose of the Study:
- To investigate the histological and ultrastructural characteristics of ovaries in women with premature ovarian failure (POF).
Main Methods:
- Light and transmission electron microscopy were employed.
- Ovarian tissue samples from ten women diagnosed with POF were analyzed.
Main Results:
- Ovaries exhibited dense connective tissue and rare corpora albicantia.
- Eight out of ten cases lacked ovarian follicles; two cases had atypical primordial follicles.
- One case showed a corpus luteum after stimulation with exogenous gonadotrophin.
- Ultrastructural analysis revealed fibroblasts forming a syncytium via cellular prolongations.
Conclusions:
- The ovarian morphology in POF is characterized by significant stromal fibrosis and a lack of functional ovarian follicles.
- Fibroblast syncytium formation may be a characteristic ultrastructural feature in POF ovaries.