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Intermittent negative pressure ventilation may increase urine flow in normal subjects
1Respiratory and Nephrology Divisions, Escola Paulista de Medicina, São Paulo.
Sao Paulo Medical Journal = Revista Paulista De Medicina
|April 1, 1994
Summary
Intermittent negative pressure ventilation (NPV) significantly increased urine flow, sodium, and potassium excretion in healthy volunteers. The exact mechanisms driving these renal function changes require further investigation.
Area of Science:
- Nephrology
- Respiratory Physiology
Background:
- Renal function is crucial for maintaining homeostasis.
- Ventilatory support can influence physiological parameters, including renal function.
Purpose of the Study:
- To investigate the impact of intermittent negative pressure ventilation (NPV) on renal function in healthy individuals.
Main Methods:
- Twenty healthy male volunteers participated in a two-phase study.
- Intermittent negative pressure ventilation (NPV) was applied using an Emerson Chest Respirator Pump.
- Renal function was assessed by measuring urine output and biochemical parameters during spontaneous breathing and NPV phases.
Main Results:
- NPV significantly increased urine flow rate (P < 0.05).
- Natriuresis and kaliuresis were significantly elevated during NPV.
- Osmolar clearance and pH also showed significant increases, while creatinine and free water clearances remained unchanged.
Conclusions:
- Intermittent negative pressure ventilation (NPV) enhances urine flow rate, natriuresis, and kaliuresis.
- The underlying physiological mechanisms responsible for these observed changes in renal function warrant further research.
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