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Updated: Aug 18, 2026

Murine Prostate Micro-dissection and Surgical Castration
Published on: May 11, 2016
Castration-induced lymphocytosis in prostate cancer: possible evidence for gonad/thymus endocrine interaction in man
R T Oliver1, J V Joseph, C J Gallagher
1Medical College, Royal London Hospital, UK.
Abstract:
Prompted by evidence from animal studies that castration produces lymphocytosis associated with thymic hyperplasia, this paper has reviewed serial lymphocyte levels in patients with prostate cancer undergoing hormone treatment. On day 7, 5 of 12 patients (58%) showed diminished circulating lymphocyte levels (compared to day 0) reflecting the surge of testosterone after treatment with LHRH analogues, while on day 28 a reversal had occurred and 13 of 17 (77%) had increased lymphocytes (compared to day 0). Possible relevance of these observations to defining a subgroup of patients with hormone-sensitive cancer who might benefit from immunotherapy is discussed.
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