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Papova viruses and recurrent laryngeal papillomatosis
1Department of Otorhynolaryngology and Pathology, Uzsoki District Hospital, Budapest, Hungary.
Abstract:
The pathogenesis of larynx papillomas has been a challenge of medical science for a long time. Both clinical observations and electronmicroscopical examinations have made it possible to establish the viral origin. Final evidence, however, has been achieved only by complicated immunohistochemical investigations. The Papova viruses--types 6 and/or 11--can be detected with in situ hybridization polymerase chain reaction amplification. HPV can be positivity demonstrated not only from visible papillomas but--in significant percentage--in neighboring healthy-looking mucous membranes. It may reveal the inadequacies of removal of lesions and the need for adjuvant therapy. To make treatment more effective we have developed a therapeutic regimen that combines CO2 laser microsurgery with immunostimulants.
Insights
Human papillomavirus (HPV) causes larynx papillomas. Detection in healthy tissue suggests recurrence risk, necessitating combined CO2 laser surgery and immunostimulant therapy for effective treatment.
Area of Science:
- Otolaryngology
- Virology
- Oncology
Background:
- Larynx papillomas present a long-standing challenge in medical science.
- Clinical and electron microscopic studies suggested a viral etiology for these tumors.
Purpose of the Study:
- To definitively establish the viral cause of larynx papillomas.
- To investigate the presence of the virus in non-lesional tissue.
- To develop an improved therapeutic strategy.
Main Methods:
- Immunohistochemical investigations were employed for definitive evidence.
- In situ hybridization and polymerase chain reaction amplification were used to detect Papova viruses (types 6 and/or 11).
- A novel therapeutic regimen combining CO2 laser microsurgery with immunostimulants was developed.
Main Results:
- Human papillomavirus (HPV) was confirmed as the causative agent.
- HPV was detected not only in visible papillomas but also in a significant percentage of adjacent healthy-appearing mucous membranes.
- The presence of HPV in healthy-appearing tissue indicates potential for lesion recurrence.
Conclusions:
- The study confirms HPV as the cause of larynx papillomas.
- Detection of HPV in seemingly healthy tissue highlights the limitations of surgical removal alone.
- Adjuvant therapy is crucial, and a combined approach of CO2 laser microsurgery and immunostimulants offers a more effective treatment regimen.