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Integrin expression in head and neck cancers
G Cortesina1, M Sacchi, M Bussi
1II ENT Department, University of Torino, Italy.
Acta Oto-Laryngologica
|March 1, 1995
Abstract:
Neoplastic transformation results in rearrangement of the cell membrane with a breakdown of the regular expression of adhesion molecules such as integrins. A relationship may exist between the intensity of this alteration, and the form it takes, and a tumour's ability to metastatise. We studied this possibility by investigating the epithelial integrin expression of 35 head and neck squamous cell carcinomas. Two types of positivity were observed: one associated with tumours with a better prognostic index, the other with those characterized by greater malignancy.