Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of the Genitourinary System III: Urine Concentration and Dilution01:20

Physiology of the Genitourinary System III: Urine Concentration and Dilution

550
The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...
550
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

990
The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
990
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

3.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.0K
Regulation of Water Intake01:25

Regulation of Water Intake

2.6K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
2.6K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.2K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.2K
Reabsorption and Secretion in the DCT and Collecting Duct01:26

Reabsorption and Secretion in the DCT and Collecting Duct

2.9K
The early phase of the DCT manages the reabsorption of approximately 10-15% of filtered water, 5–10% of filtered sodium, and 5–10% of filtered chloride. This process is facilitated by Na+–Cl− symporters in apical membranes and sodium-potassium pumps, as well as Cl− leakage channels in basolateral membranes. The early DCT also stands out as a site where parathyroid hormone (PTH) stimulates calcium reabsorption, depending on the body's requirements.
The distal...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear.

The Journal of laryngology and otology·2021
Same author

Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity.

Gene therapy·2011
Same author

Prevention and treatment of DNA vaccine encoding cockroach allergen Bla g 1 in a mouse model of allergic airway inflammation.

Allergy·2011
Same author

Expression of aquaporins and vasopressin type 2 receptor in the stria vascularis of the cochlea.

Hearing research·2009
Same author

Effects of lithium on endolymph homeostasis and experimentally induced endolymphatic hydrops.

ORL; journal for oto-rhino-laryngology and its related specialties·2005
Same author

Middle ear instillation of gentamicin and streptomycin in chinchillas: electrophysiological appraisal of selective ototoxicity.

Clinical otolaryngology and allied sciences·2002

Related Experiment Video

Updated: Jan 14, 2026

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease
04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

2.4K

Antidiuretic hormone (ADH) and endolymphatic hydrops

T Takeda1, A Kakigi, H Saito

  • 1Department of Otorhinolaryngology, Kochi Medical School, Japan.

Acta Oto-Laryngologica. Supplementum
|January 1, 1995
PubMed
Summary

Elevated plasma antidiuretic hormone (p-ADH) levels are linked to Meniere's disease and endolymphatic hydrops. These findings suggest hormonal imbalances in the inner ear may cause vertigo and hearing loss.

Area of Science:

  • Oto-neurology
  • Endocrinology
  • Internal Medicine

Background:

  • Meniere's disease is characterized by vertigo, tinnitus, and hearing loss.
  • Endolymphatic hydrops is a condition involving fluid imbalance in the inner ear.
  • The role of antidiuretic hormone (ADH) in inner ear disorders is not fully understood.

Purpose of the Study:

  • To investigate plasma antidiuretic hormone (p-ADH) concentrations in patients with vertigo, dizziness, and deafness.
  • To determine the correlation between p-ADH levels and Meniere's disease or endolymphatic hydrops.
  • To explore the potential mechanism of ADH-dependent hormonal control in vertiginous attacks.

Main Methods:

  • Radioimmunoassay was used to measure p-ADH concentrations.
  • A reversed-phase C18 silica column was employed for sample analysis.

More Related Videos

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig
06:05

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig

Published on: June 4, 2020

6.5K
Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct
11:49

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Published on: January 22, 2010

11.9K

Related Experiment Videos

Last Updated: Jan 14, 2026

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease
04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

2.4K
A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig
06:05

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig

Published on: June 4, 2020

6.5K
Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct
11:49

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Published on: January 22, 2010

11.9K
  • 300 patients with vertigo, dizziness, and/or deafness were studied, including 119 with Meniere's disease.

    • Main Results:

    • Significantly elevated p-ADH levels were observed in patients with Meniere's disease and endolymphatic hydrops.
    • p-ADH levels were lower in patients without endolymphatic hydrops.
    • Increased p-ADH levels correlated with vertigo attacks, positive glycerol tests, and enhanced negative summating potential in ECochG.

    Conclusions:

    • Disorders in ADH-dependent hormonal control in the inner ear are implicated in the pathogenesis of Meniere's disease.
    • Elevated p-ADH may be a contributing factor to vertiginous attacks and deafness in endolymphatic hydrops.
    • Further research is warranted to elucidate the precise role of ADH in inner ear fluid regulation and symptom manifestation.