Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Herpetic vestibular neuritis: an experimental study

Y Hirata1, K Gyo, N Yanagihara

  • 1Department of Otolaryngology, Ehime University School of Medicine, Japan.

Acta Oto-Laryngologica. Supplementum
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epithelial pearl formation following tympanic membrane regeneration therapy using an atelocollagen/silicone membrane and basic fibroblast growth factor: our experience from a retrospective study of one hundred sixteen patients.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2013
Same author

Antagonistic effects of two herbs in Zuojin Wan, a traditional Chinese medicine formula, on catecholamine secretion in bovine adrenal medullary cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2010
Same author

Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia through paracrine effects.

Neuroscience·2007
Same author

Value of digital volume tomography in patients with conductive hearing loss.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2005
Same author

Fundus autofluorescence in patients with pseudoxanthoma elasticum.

International ophthalmology·2003
Same author

Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils.

Gene therapy·2003

Herpes simplex virus type 1 (HSV-1) inoculation in mice created a vestibular neuritis model. This model showed significant postural deviation and vestibular dysfunction, indicating HSV-1

Area of Science:

  • Neuroscience
  • Virology
  • Otolaryngology

Background:

  • Vestibular neuritis is an inner ear disorder causing vertigo and balance issues.
  • The etiology of vestibular neuritis is often idiopathic, but viral infections are suspected.
  • Herpes simplex virus type 1 (HSV-1) is a potential candidate pathogen.

Purpose of the Study:

  • To develop and characterize an animal model of vestibular neuritis using HSV-1.
  • To investigate the pathological changes in the vestibular system following HSV-1 inoculation.
  • To assess the functional deficits associated with HSV-1-induced vestibular dysfunction.

Main Methods:

  • Herpes simplex virus type 1 (HSV-1) was inoculated into the auricle of mice.
  • Mice were observed for behavioral changes, specifically postural deviation.

Related Experiment Videos

  • Vestibular function was assessed, followed by histopathological and immunohistochemical analysis of vestibular nerves and Scarpa's ganglion.

    • Main Results:

    • A significant incidence of postural deviation and impaired vestibular function was observed in inoculated mice.
    • Histopathology revealed degeneration of Scarpa's ganglion in affected mice.
    • HSV-1 antigens were detected in the vestibular nerves of some mice with clinical signs.

    Conclusions:

    • HSV-1 inoculation into the auricle successfully established an animal model for vestibular neuritis.
    • The model demonstrates that HSV-1 can cause vestibular nerve damage and functional impairment.
    • This model provides a valuable tool for studying the pathogenesis and potential treatments for HSV-1-associated vestibular neuritis.