Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complementary peptides as recognition molecules

G Fassina1

  • 1TECNOGEN S.C.p.A., Piana di Monte Verna, (CE), Italy.

Agents and Actions. Supplements
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare professionals and patient information: a fresh look from the new italian law on consent.

La Clinica terapeutica·2021
Same author

HCV genotype 3 and squamous cell carcinoma antigen (SCCA)-IgM are independently associated with histological features of NASH in HCV-infected patients.

Journal of viral hepatitis·2015
Same author

L-Arginine does not improve endothelium-dependent relaxation inin vitro Watanabe rabbit thoracic aorta.

Amino acids·2013
Same author

Modulation of y-79 retinoblastoma cell-differentiation and IRBP expression by dibutyryl-cyclic-amp and laminin.

International journal of oncology·2011
Same author

Expression of mRNA for gelatinase A and TIMP-2 in cell cultures and tissue samples derived from breast and lung carcinomas.

International journal of oncology·2011
Same author

[Immunity and cancer: the role of PSA IgM Immune complexes for prostate cancer].

Urologia·2010
Same journal

Ro 45-2081, a TNF receptor fusion protein, prevents inflammatory responses in the airways.

Agents and actions. Supplements·1998
Same journal

Immunomodulation of Crohn's disease by interleukin-10.

Agents and actions. Supplements·1998
Same journal

Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis.

Agents and actions. Supplements·1998
Same journal

Symposium new drugs for inflammatory, allergic and immunologic disease.

Agents and actions. Supplements·1998
Same journal

The complexity of the B7-CD28/CTLA-4 costimulatory pathway.

Agents and actions. Supplements·1998
Same journal

A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.

Agents and actions. Supplements·1998
See all related articles

Researchers can design complementary peptides that bind to target peptides or proteins. These molecular recognition peptides offer applications in affinity purification, inhibiting biological interactions, and probing protein functional sites.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Peptide Chemistry

Background:

  • Molecular Recognition Theory (MRT) provides a framework for understanding molecular interactions.
  • Peptides can be designed for specific binding to target molecules.
  • Sequence-directed recognition is key to developing specific peptide interactions.

Purpose of the Study:

  • To explore the design of sequence-directed recognition peptides (complementary peptides).
  • To highlight the applications of complementary peptides based on Molecular Recognition Theory.
  • To demonstrate the utility of complementary peptides in biological research and biotechnology.

Main Methods:

  • Utilizing principles of Molecular Recognition Theory for peptide design.
  • In silico design and/or in vitro synthesis of complementary peptides.

Related Experiment Videos

  • Experimental validation of non-covalent association between complementary peptides and target peptides/proteins.

    • Main Results:

    • Successful design of complementary peptides capable of sequence-directed recognition.
    • Demonstration of non-covalent association between designed peptides and their targets.
    • Established the potential for affinity purification of target peptides/proteins.
    • Showcased the use of complementary peptides as antagonists for biological interactions.

    Conclusions:

    • Complementary peptides represent a significant application of Molecular Recognition Theory.
    • These peptides serve as versatile tools for affinity purification and biological inhibition.
    • Sequence-directed recognition peptides are valuable for probing protein-receptor interactions.