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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Research abstracts presented at the 46th annual scientific session of the Western Society of Allergy, Asthma, and Immunology.

Allergy and asthma proceedings·2017
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In Memory and Celebration: Dr. James J. Lee.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
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Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs.

The Journal of allergy and clinical immunology·2012
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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

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Upping the antedrug: is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator?

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Related Experiment Video

Updated: Jul 10, 2026

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

NIH conference. Airway inflammation

J H Shelhamer1, S J Levine, T Wu

  • 1Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

Annals of Internal Medicine
|August 15, 1995
PubMed
Summary
This summary is machine-generated.

Understanding airway inflammation mechanisms is key to treating chronic respiratory diseases like asthma and chronic bronchitis. New insights into inflammatory pathways offer potential for novel therapeutic strategies.

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Methods for Detecting Cough and Airway Inflammation in Mice
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Methods for Detecting Cough and Airway Inflammation in Mice
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Area of Science:

  • Respiratory Medicine
  • Immunology

Background:

  • Airway inflammation, secretion, and obstruction characterize common diseases such as asthma and chronic bronchitis.
  • These conditions affect millions, necessitating a deeper understanding of their underlying mechanisms.

Framework:

  • Recent research has elucidated new concepts in the initiation and perpetuation of airway inflammation.
  • Key players include chemokines, cytokines, growth factors, and lipid mediators produced by airway and inflammatory cells.

Implementation:

  • Viral respiratory infections can exacerbate airway obstruction by inducing inflammation and hyperreactivity.
  • Models explain inflammation perpetuation through neurogenic pathways and inflammatory cell recruitment cycles.

Implications:

  • A comprehensive understanding of airway inflammation mechanisms can guide the development of new clinical treatments.
  • Targeting these pathways may offer novel therapeutic approaches for chronic airway diseases.