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Related Experiment Videos

Malignant melanoma producing serotonin

T Horai, H Nishihara, S Hattori

    Cancer
    |January 1, 1979
    PubMed
    Summary
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    Malignant melanoma tumors can produce serotonin, a neurotransmitter, despite the absence of carcinoid syndrome. This finding highlights the neural crest origin of melanoma and its unique biochemical capabilities.

    Area of Science:

    • Biochemistry
    • Oncology
    • Neuroscience

    Background:

    • Malignant melanoma is a type of skin cancer.
    • Serotonin is a neurotransmitter with various physiological roles.
    • Carcinoid syndrome is a condition associated with tumors that produce serotonin.

    Observation:

    • A case study of malignant melanoma is presented where the tumor appeared to produce serotonin.
    • Clinical observation did not reveal hyperserotoninemia or carcinoid syndrome.
    • Autopsy of metastatic lung tumor showed significantly elevated serotonin levels compared to normal lung tissue.

    Findings:

    • The metastatic melanoma tumor sample contained a high concentration of serotonin (1.35 microgram/g wet weight tissue).
    • Assay of the tumor sample revealed substantial tryptophan hydroxylase activity, indicating serotonin biosynthesis.

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  • Melanoma's capacity to produce serotonin is linked to its neural crest cell origin.

    • Implications:

    • This case demonstrates an unusual biochemical function of malignant melanoma.
    • Understanding serotonin production in melanoma may offer new diagnostic or therapeutic targets.
    • The neural crest origin of melanoma provides a potential explanation for its serotonin-producing capability.