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Platelet antiaggregant methoxyphenylthienyl ketoxime ethers: synthesis and structure-activity relationships
M Varache-Lembège1, A Nuhrich, P Renard
1Laboratoire de Pharmacie chimique et Chimie thérapeutique, U.F.R. des Sciences pharmaceutiques, Université de Bordeaux II, France.
Archiv Der Pharmazie
|May 1, 1995
Abstract:
Some new oximinoalkanoic (n = 2,3,4) esters and acids derived from methoxyphenylthienyl ketones have been synthesized and evaluated in vitro for their inhibitory effects on arachidonic acid-induced human platelet aggregation. Of the eighteen oximinoethers tested the most active derivatives, which were four times more active as aspirin, belonged to the para methoxy series with Z configuration and n = 2 or 3.