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Common variable immunodeficiency (CVID) in northern India
Y N Singh1, S D Khare, A N Malaviya
1Department of Medicine, All India Institute of Medical Sciences, New Delhi.
Asian Pacific Journal of Allergy and Immunology
|December 1, 1994
Summary
Common variable immunodeficiency (CVID) patients experienced infections and malnutrition. Immunoglobulin therapy proved effective and safe for most patients, improving their health outcomes.
Area of Science:
- Immunology
- Clinical Medicine
- Human Genetics
Background:
- Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low antibody levels.
- CVID patients often present with recurrent infections, autoimmune diseases, and gastrointestinal issues.
- Understanding CVID manifestations and treatment efficacy is crucial for patient management.
Purpose of the Study:
- To investigate the clinical manifestations of CVID in a cohort of 14 patients.
- To evaluate the effectiveness and safety of immunoglobulin and/or plasma therapy in CVID patients.
- To assess the immune status, specifically IgG levels and cell-mediated immunity, in CVID patients.
Main Methods:
- Retrospective analysis of 14 patients diagnosed with CVID.
- Clinical data collection including symptoms, infections, and nutritional status.
- Assessment of serum IgG levels and cell-mediated immunity.
- Evaluation of treatment response to immunoglobulin and/or plasma therapy.
Main Results:
- Recurrent sore throat, sinusitis, respiratory infections, diarrhea, and malnutrition were the predominant clinical features.
- All patients exhibited hypogammaglobulinemia (low IgG) with preserved cell-mediated immunity.
- Immunoglobulin and/or plasma therapy demonstrated significant effectiveness in the majority of patients.
- No severe adverse events were reported during the therapeutic interventions.
Conclusions:
- CVID presents with diverse clinical manifestations, primarily recurrent infections and gastrointestinal problems.
- Immunoglobulin replacement therapy is an effective and safe treatment strategy for CVID.
- Monitoring IgG levels and clinical response is essential for optimizing CVID management.