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Common variable immunodeficiency (CVID) in northern India

Y N Singh1, S D Khare, A N Malaviya

  • 1Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Asian Pacific Journal of Allergy and Immunology
|December 1, 1994
PubMed
Summary

Common variable immunodeficiency (CVID) patients experienced infections and malnutrition. Immunoglobulin therapy proved effective and safe for most patients, improving their health outcomes.

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Area of Science:

  • Immunology
  • Clinical Medicine
  • Human Genetics

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low antibody levels.
  • CVID patients often present with recurrent infections, autoimmune diseases, and gastrointestinal issues.
  • Understanding CVID manifestations and treatment efficacy is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical manifestations of CVID in a cohort of 14 patients.
  • To evaluate the effectiveness and safety of immunoglobulin and/or plasma therapy in CVID patients.
  • To assess the immune status, specifically IgG levels and cell-mediated immunity, in CVID patients.

Main Methods:

  • Retrospective analysis of 14 patients diagnosed with CVID.

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  • Clinical data collection including symptoms, infections, and nutritional status.
  • Assessment of serum IgG levels and cell-mediated immunity.
  • Evaluation of treatment response to immunoglobulin and/or plasma therapy.

    • Main Results:

    • Recurrent sore throat, sinusitis, respiratory infections, diarrhea, and malnutrition were the predominant clinical features.
    • All patients exhibited hypogammaglobulinemia (low IgG) with preserved cell-mediated immunity.
    • Immunoglobulin and/or plasma therapy demonstrated significant effectiveness in the majority of patients.
    • No severe adverse events were reported during the therapeutic interventions.

    Conclusions:

    • CVID presents with diverse clinical manifestations, primarily recurrent infections and gastrointestinal problems.
    • Immunoglobulin replacement therapy is an effective and safe treatment strategy for CVID.
    • Monitoring IgG levels and clinical response is essential for optimizing CVID management.