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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Src family protein tyrosine kinases and cellular signal transduction pathways

T Erpel1, S A Courtneidge

  • 1Differentiation Programme, EMBL, Heidelberg, Germany.

Current Opinion in Cell Biology
|April 1, 1995
PubMed

Insights

Src family kinases are crucial for cell growth and architecture, interacting with various receptors to mediate signaling. They play key roles in cell division and in response to cellular stress.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Src family kinases are implicated in crucial cellular processes.
  • These kinases interact with both receptor tyrosine kinases and non-kinase receptors.

Purpose of the Study:

  • To elucidate the role of Src family kinases in signal transduction pathways.
  • To understand their involvement in cell growth, architecture, and response to stimuli.

Main Methods:

  • Investigating interactions between Src family kinases and receptor tyrosine kinases (e.g., platelet-derived growth factor receptor).
  • Examining interactions with receptors lacking intrinsic tyrosine kinase activity (e.g., interleukin-2 receptor).
  • Analyzing Src family kinase activation during stress and mitosis.

Main Results:

  • Src family kinases are essential for mitogenic signaling mediated by certain receptors.
  • These kinases are activated in response to cellular stress.
  • Src family kinases are also activated during mitosis, suggesting a role in cell division.

Conclusions:

  • Src family kinases are versatile signaling molecules involved in diverse cellular functions.
  • Their interactions with various receptors highlight their central role in signal transduction.
  • Activation during stress and mitosis underscores their importance in cell survival and proliferation.

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