Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell adhesion molecules in rheumatoid arthritis

D O Haskard1

  • 1Department of Medicine (Rheumatology Unit), Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Current Opinion in Rheumatology
|May 1, 1995
PubMed
Summary

Understanding leukocyte adhesion molecules is key for treating inflammatory diseases like rheumatoid arthritis. Research is advancing our knowledge of these molecules

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet's Syndrome.

Scientific reports·2016
Same author

The exaggerated inflammatory response in Behçet's syndrome: identification of dysfunctional post-transcriptional regulation of the IFN-γ/CXCL10 IP-10 pathway.

Clinical and experimental immunology·2015
Same author

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation.

Annals of the rheumatic diseases·2015
Same author

Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17.

Annals of the rheumatic diseases·2014
Same author

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma.

Oncogene·2012
Same author

Persistence of TNFalpha in diabetic wounds.

Diabetologia·2010

Area of Science:

  • Immunology and Rheumatology
  • Cellular Biology
  • Molecular Medicine

Background:

  • Leukocyte adhesion mechanisms are crucial for immune cell migration into inflamed tissues.
  • Understanding these interactions is vital for developing treatments for inflammatory conditions.

Purpose of the Study:

  • To review recent advances in understanding leukocyte adhesion molecules in inflammation.
  • To explore the roles of specific adhesion molecules in leukocyte-endothelial cell interactions.
  • To assess the potential of targeting adhesion molecules for anti-inflammatory therapies.

Main Methods:

  • Literature review of recent research on adhesion molecules.
  • Analysis of studies on novel adhesion molecule expression in rheumatoid synovium.
  • Examination of reports on soluble adhesion molecule measurements.

Main Results:

  • Significant progress has been made in elucidating the specific functions of individual adhesion molecules.
  • Novel adhesion molecules have been identified in rheumatoid synovium.
  • Soluble adhesion molecule levels are being measured, but clinical utility is yet to be determined.

Conclusions:

  • Continued investigation into adhesion mechanisms is essential for advancing inflammatory disease treatment.
  • Targeting adhesion molecule function presents a promising therapeutic strategy for anti-inflammatory therapy.

Related Experiment Videos