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Delayed gastric emptying as a factor in delayed postprandial glycaemic response in pregnancy
K Stanley1, A Magides, M Arnot
1University Department of Obstetrics, Northern General Hospital, Sheffield, UK.
Objective:
To determine whether an alteration in gastric emptying contributes to an altered postprandial glycaemic response in normal pregnancy.
Design:
A longitudinal study in normal pregnancy and postpartum.
Setting:
Teaching hospital in Sheffield.
Subjects:
Primigravid women with uncomplicated pregnancies.
Interventions:
Simultaneous meal tolerance and paracetamol absorption tests.
Main Outcome Measures:
1. Gastric emptying: maximum concentration (Cmax) and time to maximum concentration (Tmax) of paracetamol; 2. glycaemic response: Cmax, Tmax, and area under the curve of plasma glucose; 3. insulinaemic response: Cmax, Tmax, area under the curve of plasma insulin.
Results:
An increased, but not delayed, insulin response, and an increased initial glucose response to a test meal in the third trimester were not accompanied by any simultaneous delay in gastric emptying.
Conclusion:
Gastric emptying does not seem to be a factor in the glycaemic response of pregnancy.