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Related Experiment Videos

Our first 100 consecutive pediatric liver transplants

J Vazquez1, M L Santamaria, J Murcia

  • 1Department of Pediatric Surgery, Hospital Infantil La Paz, Madrid, Spain.

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|April 1, 1995
PubMed
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Pediatric transplantation·2013

Pediatric orthotopic liver transplantation (OLT) is a successful treatment for end-stage liver disease, with a 5-year survival rate of 75% in children, even for those under 20 kg. This study analyzes 100 OLTs in children, highlighting indications and outcomes.

Area of Science:

  • Pediatric Surgery
  • Hepatology
  • Transplantation Immunology

Background:

  • Orthotopic liver transplantation (OLT) is the primary treatment for end-stage liver disease.
  • Pediatric OLT presents unique challenges compared to adult transplantation.
  • The efficacy of dedicated pediatric OLT programs requires ongoing evaluation.

Purpose of the Study:

  • To analyze the outcomes of the first 100 consecutive pediatric orthotopic liver transplantations (OLTs) at a single center.
  • To assess the feasibility and results of OLT in children, particularly those with low body weight.
  • To identify indications, complications, and survival rates in pediatric liver recipients.

Main Methods:

  • Retrospective analysis of 100 OLTs performed in 78 pediatric patients between 1986 and the study period.

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  • Evaluation of patient demographics, indications for transplantation, graft types, retransplantation rates, and complications.
  • Assessment of acute and chronic rejection episodes and their management, alongside surgical complications and survival data.

    • Main Results:

    • 100 OLTs were performed in 78 children, with 61% weighing less than 20 kg.
    • Common indications included cholestasis (45%), metabolic disease (18%), and cirrhosis (10%).
    • Five-year actuarial survival rate was 75%, with significant rates of acute rejection (52%) and surgical complications like hepatic artery thrombosis (12%) and biliary issues (13%).

    Conclusions:

    • Pediatric OLT is a viable and effective treatment for end-stage liver disease in children, even in low-weight recipients.
    • Careful management of rejection and surgical complications is crucial for improving long-term outcomes.
    • Dedicated pediatric liver transplant programs can achieve favorable survival rates, supporting their continued necessity.