Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucotractive effect of lectin

D L Freed, C H Buckley

    Lancet (London, England)
    |March 18, 1978
    PubMed
    Summary
    This summary is machine-generated.

    The jackbean lectin, concanavalin A, stimulated mucus secretion in human noses and rat intestines. This finding suggests potential therapeutic applications for conditions like cystic fibrosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye.

    The British journal of ophthalmology·2005
    Same author

    Functional heterogeneity of large and small resistance arteries isolated from biopsies of subcutaneous fat: implications for investigation of vascular pathophysiology.

    General pharmacology·2001
    Same author

    Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries.

    British journal of pharmacology·2001
    Same author

    Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma.

    BJOG : an international journal of obstetrics and gynaecology·2001
    Same author

    p53 and related proteins in epithelial ovarian cancer.

    European journal of cancer (Oxford, England : 1990)·2000
    Same author

    Requirement for expert histopathological assessment of ovarian cancer and borderline tumors.

    British journal of cancer·2000

    Area of Science:

    • Biochemistry
    • Physiology
    • Gastroenterology

    Background:

    • Mucus hypersecretion is a hallmark of various diseases.
    • Goblet cells are responsible for mucus production in the gastrointestinal and respiratory tracts.
    • Understanding the regulation of mucus secretion is crucial for therapeutic development.

    Purpose of the Study:

    • To investigate the effect of jackbean lectin concanavalin A on mucus secretion.
    • To explore the potential therapeutic implications of concanavalin A's "mucotractive" properties.

    Main Methods:

    • Administration of concanavalin A to human nasal and rat jejunal models.
    • Histological examination of jejunal tissue to assess goblet cell activity.

    Main Results:

    Related Experiment Videos

    • Concanavalin A induced significant mucus hypersecretion in both human nasal and rat jejunal models.
    • Histology confirmed increased goblet cell emptying, indicating active mucus release.
    • The observed effect was termed "mucotractive".

    Conclusions:

    • Concanavalin A possesses a "mucotractive" effect, stimulating mucus secretion.
    • This finding has potential relevance to the fibre hypothesis.
    • Concanavalin A may offer a novel therapeutic strategy for cystic fibrosis patients.