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The Escherichia coli RNA polymerase alpha subunit: structure and function
1Department of Chemistry, Rutgers University, New Brunswick, New Jersey 08855, USA.
Current Opinion in Genetics & Development
|April 1, 1995
Abstract:
Recent work has established that the Escherichia coli RNA polymerase alpha subunit consists of an amino-terminal domain containing determinants for interaction with the remainder of RNA polymerase, a carboxy-terminal domain containing determinants for interaction with DNA and interaction with transcriptional activator proteins, and a 13-36 amino acid unstructured and/or flexible linker. These findings suggest a simple, integrated model for the mechanism of involvement of alpha in promoter recognition and transcriptional activation.