Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in allergic inflammation associated with successful immunotherapy

S R Durham1, A B Kay, Q Hamid

  • 1Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK.

International Archives of Allergy and Immunology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunosuppression in Chronic Asthma.

International archives of allergy and immunology·2021
Same author

The early history of the eosinophil.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same author

Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous ('idiopathic') urticaria.

The British journal of dermatology·2014
Same author

Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same author

Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin.

The British journal of dermatology·2014
Same author

Immunotherapy is allergen-specific: a double-blind trial of mite or timothy extract in mite and grass dual-allergic patients.

International archives of allergy and immunology·2012

Allergen immunotherapy and topical corticosteroids effectively reduce late nasal responses by inhibiting T cell and eosinophil recruitment. Immunotherapy promotes a Th1 response, while corticosteroids suppress Th2 cytokines like interleukin-4.

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • Allergen injection immunotherapy offers anti-inflammatory effects, modulating antibody responses and reducing mast cell and eosinophil activity.
  • Late nasal responses to allergens involve T cell and eosinophil recruitment, contributing to symptoms.

Purpose of the Study:

  • To compare the effects of allergen immunotherapy and topical corticosteroids on allergen-induced late nasal responses.
  • To elucidate the distinct mechanisms by which these treatments modulate the inflammatory cascade.

Main Methods:

  • Comparison of allergen immunotherapy versus topical corticosteroid treatment.
  • Assessment of late nasal responses, including symptom severity, CD4+ T cell, and eosinophil recruitment.
  • Analysis of cytokine mRNA expression, specifically Th1 (interferon-gamma) and Th2 (interleukin-4) related.

Related Experiment Videos

Main Results:

  • Both immunotherapy and topical corticosteroids effectively inhibit late nasal symptoms and the recruitment of CD4+ T cells and eosinophils.
  • Topical corticosteroids appear to suppress Th2-type cytokine mRNA expression, such as interleukin-4.
  • Allergen immunotherapy induces a local Th1 response, evidenced by increased interferon-gamma.

Conclusions:

  • Allergen immunotherapy and topical corticosteroids are effective in managing allergen-induced late nasal responses through distinct immunomodulatory pathways.
  • Immunotherapy shifts the immune response towards a Th1 profile, whereas corticosteroids act via Th2 cytokine suppression.