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Buspirone inhibits contact hypersensitivity in the mouse
M H McAloon1, A ChandraSekar, Y J Lin
1Arcturus Pharmaceutical Corporation, Woburn, MA 01801, USA.
International Archives of Allergy and Immunology
|May 1, 1995
Summary
Buspirone HCl, a common drug, was found to have immunosuppressive activity. This new finding shows buspirone can reduce swelling and immune cell infiltration in a mouse model of hypersensitivity.
Area of Science:
- Immunology
- Pharmacology
- Dermatology
Background:
- Buspirone HCl is a widely used anxiolytic medication.
- Its known therapeutic applications do not include immunosuppression.
- Contact hypersensitivity is an immune response mediated by T-cells.
Purpose of the Study:
- To investigate the potential immunosuppressive activity of buspirone HCl.
- To assess the efficacy of buspirone HCl in a mouse model of contact hypersensitivity.
Main Methods:
- Administration of buspirone HCl either topically or systemically in mice.
- Induction of contact hypersensitivity.
- Assessment of tissue swelling and leukocyte infiltration during the elicitation phase.
Main Results:
- Topical and systemic administration of buspirone HCl significantly reduced tissue swelling.
- Buspirone HCl significantly decreased leukocyte infiltration in the affected tissues.
- These effects were observed in the context of the elicitation phase of contact hypersensitivity.
Conclusions:
- Buspirone HCl exhibits previously unrecognized immunosuppressive properties.
- The findings suggest a potential new therapeutic application for buspirone HCl in managing hypersensitivity reactions.
- Buspirone HCl's safety profile supports further investigation into its immunomodulatory effects.