Physiological characterization of pretectal neurons projecting to the lateral posterior-pulvinar complex in the cat

Pretectal neurons projecting to the lateral posterior-pulvinar complex (LP-P) in cats were electrophysiologically identified by their antidromic activation from the LP-P. Their responses to various visual stimuli and to electrical stimulation of the optic chiasm and the lateral geniculate nucleus (LGN) were characterized. In retrograde double-labelling experiments, the pretectal projections to the LP-P and to the LGN were tested for possible overlap. Forty-five neurons were antidromically activated from the LP-P; 55% of them could also be activated orthodromically from the optic chiasm. Most antidromically activated neurons responded to rapid movements of large textured visual stimuli as well as to 'on' or 'off' visual stimulation with short bursts. When stimulated with a slowly moving, large, structured visual stimulus, most cells showed a slight but significant activity increase. None of the neurons projecting to the LP-P was also activated antidromically from the LGN. Thus, the two populations are separate. This is supported by the results from the retrograde double-labelling experiments. None of the LP-P projecting neurons showed any directional selectivity to slow movements of large visual stimuli, a property by which pretectal neurons projecting to the inferior olive are characterized. Thus, neurons projecting to the LP-P do not bifurcate to the inferior olive. Response properties of neurons projecting to the LP-P were very similar to those of the 'jerk' neurons described by Schweigart and Hoffmann (Exp. Brain Res., 91, 273-283, 1992); therefore we believe them to be identical.(ABSTRACT TRUNCATED AT 250 WORDS)