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Related Experiment Videos

Lingual hyperpigmentation associated with minocycline therapy

M A Meyerson1, P R Cohen, S R Hymes

  • 1Department of Dermatology, University of Texas-Houston Medical School, USA.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|February 1, 1995
PubMed
Summary

Minocycline can cause skin and oral pigmentation. This study highlights two cases of isolated tongue pigmentation in women taking minocycline, suggesting it as a potential diagnosis.

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Area of Science:

  • Dermatology
  • Oral Medicine
  • Pharmacology

Background:

  • Minocycline is known to cause hyperpigmentation affecting the conjunctiva, oral mucosa, and skin.
  • Oral mucosal pigmentation can result from various endogenous and exogenous factors.
  • Isolated lingual pigmentation has differential diagnoses including Addison's disease, amalgam tattoos, and malignant melanoma.

Observation:

  • Two female patients presented with isolated pigmentation solely on their tongues.
  • These patients were concurrently undergoing treatment with minocycline.
  • No concurrent pigmentation of the skin or other oral mucosal surfaces was observed in these cases.

Findings:

  • Minocycline can induce isolated lingual hyperpigmentation.
  • This specific presentation is not commonly associated with other minocycline-induced pigmentations.

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  • The observed cases expand the known spectrum of minocycline's side effects.

    • Implications:

    • Minocycline-induced lingual pigmentation should be considered in the differential diagnosis of isolated tongue hyperpigmentation.
    • Clinicians should be aware of this potential side effect when prescribing minocycline.
    • Further research may be warranted to understand the mechanism and prevalence of isolated minocycline-induced lingual pigmentation.