Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Dialysis-associated amyloidosis

T Drüeke¹, M Touam, J Zingraff

¹INSERM Unité 90, Hôpital Necker, Paris, France.

Advances in Renal Replacement Therapy

|January 1, 1995

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[A rare cause of chondritis].

La Revue de medecine interne·2014

Same author

Is renal allograft dysfunction a risk factor for severe infection in kidney transplant recipients?

Transplantation proceedings·2012

Same author

[Cinacalcet treatment for secondary hyperparathyroidism in dialysis patients in real-world clinical practice - the ECHO observational study: French experience].

Nephrologie & therapeutique·2012

Same author

Introduction: improving outcomes in chronic kidney disease.

Kidney international. Supplement·2006

Same author

Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).

Kidney international·2006

Same author

[Indications of central venous access in the context of acute renal insufficiency].

Nephrologie·2002

Same journal

Needed: a catalyst for change.

Advances in renal replacement therapy·2004

Same journal

Racial and ethnic differences in the incidence and progression of focal segmental glomerulosclerosis in children.

Advances in renal replacement therapy·2004

Same journal

Incorporating ethnic and cultural food preferences in the renal diet.

Advances in renal replacement therapy·2004

Same journal

Literature review and implications for social work practice with Hispanic dialysis patients.

Advances in renal replacement therapy·2004

Same journal

Diversity and patient care in a shrinking world.

Advances in renal replacement therapy·2004

Same journal

Genetic variation in the epithelial sodium channel: a risk factor for hypertension in people of African origin.

Advances in renal replacement therapy·2004

See all related articles

Dialysis-related arthropathy is linked to beta-2 microglobulin (beta 2-M) amyloidosis. Advances in dialysis technology may reduce this complication by improving beta 2-M removal and biocompatibility.

Area of Science:

Nephrology
Rheumatology
Biochemistry

Background:

Dialysis-related arthropathy is a significant complication in patients undergoing renal replacement therapy.
This condition is associated with beta-2 microglobulin (beta 2-M) amyloidosis.

Purpose of the Study:

To explore the pathogenesis of dialysis-related arthropathy.
To investigate the role of beta-2 microglobulin (beta 2-M) and potential contributing factors.

Main Methods:

Review of existing literature on beta-2 microglobulin (beta 2-M) amyloidosis and dialysis complications.
Analysis of factors influencing beta-2 microglobulin (beta 2-M) metabolism and deposition.

Main Results:

Chronic renal failure leads to beta-2 microglobulin (beta 2-M) retention, a prerequisite for amyloidosis.

Related Experiment Videos

Inflammatory mediators, altered beta 2-M metabolism, and dialysis membrane biocompatibility may also contribute to pathogenesis.

Modern dialysis techniques, including high-flux dialyzers, can enhance beta 2-M removal and reduce procedure bioincompatibility.

Conclusions:

While beta-2 microglobulin (beta 2-M) retention is key, other factors are involved in dialysis-related arthropathy.
Technical advancements in dialysis may decrease the incidence of symptomatic beta 2-M amyloidosis.