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Resistance to azole drugs in Neurospora crassa
1T.H. Morgan School of Biological Sciences, University of Kentucky, Lexington 40506-0225, USA.
Experimental Mycology
|June 1, 1995
Abstract:
Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 microgram/ml), fluconazole (MIC 5 micrograms/ml), and SCH39304 (MIC 5 micrograms/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not all, were also resistant to fluconazole and to SCH39304.