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Related Experiment Videos

Xa receptor EPR-1

D C Altieri1

  • 1Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 1, 1995
PubMed
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Factor Xa binding to cells activates coagulation and triggers intracellular signals regulating cell growth. Effector cell protease receptor-1 (EPR-1) emerges as a key regulator in these vascular disease processes.

Area of Science:

  • Vascular Biology
  • Cellular Signaling
  • Hemostasis

Background:

  • Inflammatory responses and vascular injury involve blood coagulation and fibrin deposition.
  • Factor Xa on cell surfaces generates thrombin, initiating coagulation.
  • Emerging evidence shows factor Xa binding to cells triggers intracellular signaling pathways.

Purpose of the Study:

  • To investigate the role of factor Xa in cellular signal transduction beyond thrombin generation.
  • To identify and characterize novel cellular binding sites for factor Xa.
  • To explore the potential of effector cell protease receptor-1 (EPR-1) in regulating factor Xa-mediated signaling and vascular disease.

Main Methods:

  • Investigated factor Xa interactions with vascular cells (leukocytes, endothelium, smooth muscle cells).

Related Experiment Videos

  • Identified effector cell protease receptor-1 (EPR-1) as a cellular binding site for factor Xa.
  • Examined EPR-1's role in intracellular signal transduction and cellular growth regulation.

    • Main Results:

    • Factor Xa binding to vascular cells initiates complex intracellular signaling pathways.
    • Effector cell protease receptor-1 (EPR-1) was identified as a novel regulator of factor Xa-mediated mitogenic signaling.
    • EPR-1 influences leukocyte subsets, costimulates lymphocyte proliferation, and is regulated by alternative mRNA splicing.

    Conclusions:

    • Factor Xa's role extends beyond coagulation to regulating vascular cell growth through intracellular signaling.
    • EPR-1 is a significant mediator of factor Xa's effects on cellular growth and may contribute to vascular disease pathogenesis.
    • Further research into EPR-1 could offer insights into treating vascular diseases.