Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Morphophysiological characteristics of Hymenaea martiana Hayne seeds in Northeastern Brazil are influenced by interannual environmental variations.

Brazilian journal of biology = Revista brasleira de biologia·2026
Same author

Phenolphitalein-exudate pH test in the evaluation of Crateva tapia L. seed viability.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Exploring pathogen-specific somatic cell patterns in dairy ewes during early lactation.

Journal of dairy science·2025
Same author

Biometric aspects of fruits and seeds and determination of the absorption curve of Hymenaea martiana Hayne seeds.

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs.

Stem cell research & therapy·2021
Same author

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease.

United European gastroenterology journal·2018
Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026
Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026
Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026
Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026
Same journal

Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.

Gastroenterology·2026
Same journal

Reply.

Gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2026

Creation of Reversible Cholestatic Rat Model
09:39

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than

C M Rodrigues1, B T Kren, C J Steer

  • 1Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Gastroenterology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Tauroursodeoxycholic acid (TUCDA) shows greater hepatoprotective effects than ursodeoxycholic acid (UDCA) by increasing liver UDCA concentration and reducing toxic bile acids. This is due to enhanced liver uptake and decreased intestinal processing, not better absorption.

More Related Videos

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

Related Experiment Videos

Last Updated: Jul 6, 2026

Creation of Reversible Cholestatic Rat Model
09:39

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

Area of Science:

  • Hepatology
  • Bile Acid Metabolism
  • Pharmacokinetics

Background:

  • Ursodeoxycholic acid (UDCA) is a widely used therapeutic bile acid.
  • Tauroursodeoxycholic acid (TUCDA) exhibits a more potent hepatoprotective effect than UDCA.
  • The underlying mechanisms for TUCDA's superior efficacy require elucidation.

Purpose of the Study:

  • To compare the absorption, hepatic enrichment, and biotransformation of TUCDA and UDCA in rats.
  • To explain the enhanced hepatoprotective action of TUCDA.

Main Methods:

  • Rats were administered 250 mg/day of either TUCDA or UDCA.
  • Bile acids and their metabolites were quantified in intestinal contents, feces, urine, plasma, and liver.
  • Gas chromatography-mass spectrometry was employed for precise bile acid determination.

Main Results:

  • Hepatic ursodeoxycholate concentration was significantly higher in rats treated with TUCDA (175 nmol/g) compared to UDCA (79 nmol/g).
  • TUCDA administration led to lower hepatic lithocholate levels and a greater reduction in hydrophobic bile acids.
  • Increased ursodeoxycholate and reduced lithocholate were observed in the intestinal tract and feces following TUCDA treatment.

Conclusions:

  • TUCDA enhances hepatic ursodeoxycholate concentration and reduces toxic bile acids more effectively than UDCA.
  • These effects are attributed to increased hepatic extraction and diminished intestinal biotransformation of TUCDA.
  • Enhanced absorption of TUCDA does not explain its superior hepatoprotective properties.