Related Experiment Video
Updated: Apr 28, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Ecstasy induced hepatitis mimicking viral hepatitis
R S Dykhuizen1, P W Brunt, P Atkinson
1Infection Unit, City Hospital, Aberdeen.
Abstract:
Three cases of jaundice after ingestion of 3,4-methylenedioxymetamphetamine (MDMA), known as 'ecstasy', are reported and the complications associated with the misuse of this drug, which was initially misrepresented as 'safer than alcohol' are described. Ingestion of 'ecstasy' should be considered when investigating unexplained jaundice in younger patients.
Insights
Jaundice can occur after taking 3,4-methylenedioxymetamphetamine (MDMA), or ecstasy. Doctors should consider MDMA use in young patients with unexplained jaundice.
Area of Science:
- Hepatology
- Toxicology
- Pharmacology
Background:
- 3,4-methylenedioxymetamphetamine (MDMA), commonly known as 'ecstasy', is a recreational drug often misrepresented as safe.
- Hepatotoxicity is a potential adverse effect of recreational drug use, including MDMA.
Observation:
- This report details three cases of patients presenting with jaundice following the ingestion of MDMA.
- The clinical presentation and diagnostic process for these cases are described.
Findings:
- MDMA ingestion was identified as the cause of jaundice in these three patients.
- Complications arising from MDMA misuse, including liver injury, are highlighted.
Implications:
- Unexplained jaundice in younger individuals should prompt consideration of MDMA (ecstasy) use.
- This underscores the importance of comprehensive drug history in patients with acute liver injury.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Myocarditis III: Medical Management
Cytomegalovirus Disease
Hepatitis
Viral Hepatitis I: Introduction
Hepatic Encephalopathy

