Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Manic-depression and the norepinephrine transporter gene

D Hadley1, M Hoff, J Holik

  • 1Department of Psychiatry, University of Utah Medical Center, Salt Lake City.

Human Heredity
|May 1, 1995
PubMed
Summary

This study investigated the norepinephrine transporter (NET) gene

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutron-Multiplicity Measurement in Muon Capture on Oxygen Nuclei in the Gadolinium-Loaded Super-Kamiokande Detector.

Physical review letters·2026
Same author

Are birth characteristics related to bone quality measures in young adults? The HUNT study, Norway.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Birth Characteristics and Bone Mineral Density and Content in Young Adults: The HUNT Study, Norway.

Calcified tissue international·2025
Same author

First Joint Oscillation Analysis of Super-Kamiokande Atmospheric and T2K Accelerator Neutrino Data.

Physical review letters·2025
Same author

Is there an association between birth characteristics and fractures in young adults? The HUNT Study, Norway.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
Same author

Search for Periodic Time Variations of the Solar ^{8}B Neutrino Flux between 1996 and 2018 in Super-Kamiokande.

Physical review letters·2024

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Manic-depression (bipolar disorder) is a complex psychiatric condition with a significant genetic component.
  • The norepinephrine transporter (NET) plays a crucial role in regulating neurotransmitter levels in the brain, making it a candidate gene for mood disorders.

Purpose of the Study:

  • To investigate the potential linkage between the norepinephrine transporter (NET) gene and manic-depression (bipolar disorder).

Main Methods:

  • Genotyping of a DNA polymorphism within the NET gene in six multigenerational pedigrees.
  • Analysis of genetic linkage using both parametric and nonparametric statistical methods.

Main Results:

  • No statistically significant evidence of linkage was found between the NET gene and manic-depression in the studied pedigrees.
  • This suggests the NET gene is unlikely to be a major susceptibility locus for manic-depression in these families.

Conclusions:

  • The norepinephrine transporter (NET) gene does not appear to be a primary genetic factor for manic-depression in the investigated multigenerational families.
  • Further genetic studies are warranted to identify genes associated with manic-depression.

Related Experiment Videos