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Related Experiment Videos

Effect of eccentric exercise on natural killer cell activity

J Palmø1, S Asp, J R Daugaard

  • 1Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, Denmark.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 1, 1995
PubMed
Summary

Eccentric exercise, even with a small muscle group, boosts natural killer (NK) cell percentage and activity systemically. This immune response is linked to increased plasma epinephrine levels.

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Area of Science:

  • Exercise immunology
  • Skeletal muscle physiology
  • Cellular immunology

Background:

  • Natural killer (NK) cells are crucial for innate immunity.
  • Eccentric exercise involves muscle lengthening under load.
  • Understanding exercise's impact on immune cells is vital for health.

Purpose of the Study:

  • To investigate the systemic effects of one-legged eccentric exercise on NK cell activity.
  • To differentiate between local and systemic immune responses to exercise.
  • To explore the relationship between eccentric exercise and specific immune cell populations.

Main Methods:

  • Eight healthy males performed one-legged eccentric exercise.
  • Blood samples were collected from exercising leg and resting arm veins.

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  • NK cell percentage and activity were measured, along with other immune cell markers and creatine kinase.

    • Main Results:

    • Eccentric exercise increased plasma creatine kinase levels.
    • The percentage of CD16+ NK cells and NK cell activity per mononuclear cell increased systemically.
    • NK cell activity per NK cell did not change; other immune cell percentages remained stable.

    Conclusions:

    • Eccentric exercise, even involving a small muscle mass, induces systemic effects on NK cells.
    • Increased plasma epinephrine during eccentric exercise may drive the observed rise in CD16+ NK cells.
    • These findings highlight the systemic immune modulation following localized eccentric muscle contractions.