Related Experiment Videos
[Clinicopathological study on atherosclerosis of the right gastroepiploic arteries]
K Shimizu1, T Sakamoto, N Miura
1Department of Thoracic and CArdiovascular Surgery, Tokyo Medical and Dental University, School of Medicine, Japan.
Insights
This study assessed atherosclerosis in right gastroepiploic arteries (RGEAs) used for coronary bypass grafting. Findings reveal significant arteriosclerotic lesions, impacting graft suitability for ischemic heart disease patients.
Area of Science:
- Vascular Surgery
- Cardiovascular Pathology
- Histopathology
Context:
- Right gastroepiploic arteries (RGEAs) are utilized as graft materials in coronary bypass grafting for ischemic heart disease.
- The prevalence and characteristics of atherosclerosis in RGEAs require thorough evaluation to ensure graft efficacy.
- Gastrectomy patients undergoing early gastric cancer treatment provide a cohort for studying RGEA atherosclerosis.
Purpose:
- To evaluate the extent and predilection sites of atherosclerosis in RGEAs.
- To analyze the relationship between arteriosclerotic lesions in RGEAs and clinical risk factors for ischemic heart disease.
- To grade the severity of atherosclerosis in RGEAs based on quantitative measurements.
Summary:
- 32 patients (18 male, 14 female; age 32-80) undergoing gastrectomy for gastric cancer were analyzed.
- RGEAs were sectioned and stained to quantify intimal and medial areas, calculating a stenosis index (R).
- Atherosclerosis was graded based on the R value, with higher grades indicating more severe stenosis.
Impact:
- Provides critical data on the suitability of RGEAs as bypass grafts by quantifying atherosclerotic burden.
- Highlights the need to consider graft quality in surgical planning for ischemic heart disease.
- Contributes to understanding arterial disease progression and its clinical implications in graft selection.
Abstract:
We evaluated the extent of atherosclerosis of the right gastroepiploic arteries (RGEAs) used as a graft material in coronary bypass grafting for ischemic heart diseases, with analyzing the presence of arteriosclerotic lesions and the site of predilection and studying their relationship to clinical risk factors of ischemic heart disease. The subjects were 32 cases, 18 males and 14 females, ranging in age from 32 to 80 years (mean 61 years), in which gastrectomy was performed for early gastric cancer. RGEA 20 cm in length was taken from the junction of the gastroduodenal artery of the stomach and divided into A, B, C and D at intervals of 5 cm proximally, and each part was subdivided into the length of about 5 mm to make ultra-thin sections for HE and Elastica van Gieson staining. The area of intima (I), the area of media (M) and circumference of media (L) were calculated. The arterial section was transformed to a hypothetical state in which the internal elastic lamina was stretched to make an exact circle. The degree of stenosis "I" was expressed by the following formula. [formula: see test] The maximum value of "I" in the sections A, B, C and D in individual cases was designated as Ar, Br, Cr and Dr, and the maximum value of "I" among the four sections in each case was defined as R. Atherosclerosis was graded according to R value as follows. I; R < 25%, II; 25% < or = R < 50%, III; 50% < or = R < 75%, IV; 75% < or = R.(ABSTRACT TRUNCATED AT 250 WORDS)